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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

One previous study showed that patients with history of MBS and cholecystectomy had higher postprandial levels of insulin and C4 (a marker of hepatic BA synthesis) than patients with history of MBS who did not undergo cholecystectomy [11]

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Exe4 secretion in hepatocyte-derived cell lines A series of Exe secretion plasmids containing various SP and FCS (each 1 g) were transfected into Hepa1-6 and HepG2 cells in 12-well plates using Lipofectamine 3000 (Invitrogen) according to the manufactures protocol