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Preparation : After cleaning the area, a topical anesthetic could be applied to help to reduce its pain

Polyneuropathy typically presents gradually, beginning with paresthesia known as burning feet, followed by gait disturbances and variable muscle weakness in the lower limbs ( In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (42)

showed improved results in patients with metastatic CRC and led to longer survival time compared with the control group [136]

Melanotan 2 is a synthetic analogue of alpha-melanocyte-stimulating hormone (-MSH)