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Important milestones in the GHK-Cu literature include the original 1973 identification of GHK as a plasma-derived cell proliferation factor, the recognition of the copper-binding role in the late 1970s, the wound healing and collagen research of the 1980s and 1990s, the establishment of GHK-Cu as a cosmetic ingredient in the 1990s and 2000s, and the transcriptomic expansion of the research literature in the 2000s and 2010s

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Furthermore, nanoencapsulation is effective for enhancing the activity of essential oils [158] and facilitating targeted delivery of phytochemicals, as demonstrated in treatments such as liver fibrosis using modified hyaluronate sodium and phosphatidylserine LNC [159], and lectin-based nanocapsules targeting intestinal mucositis [160]