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Division of Dermatology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa ABSTRACT BACKGROUND: Glutathione (GSH) is the most abundant naturally occurring non-protein thiol that protects mammalian cells from oxidative stress

Glutathione exists in two primary states within the cell: Reduced glutathione (GSH): The active, antioxidant form Oxidized glutathione (GSSG): The spent form, converted back to GSH by the enzyme glutathione reductase using NADPH Under healthy physiological conditions, more than 98% of cellular glutathione exists in the reduced (active) form