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GLP-1RA corrects this imbalance through the following mechanisms: cell function protection and regeneration: GLP-1RA not only promotes insulin synthesis through cAMP-PKA pathway, but also realizes the increase of cell number and functional recovery by inhibiting cell apoptosis and promoting cell to cell transdifferentiation (for example, GCGR monoclonal antibody combined with GLP-1RA treatment can triple the number of cells in type 1 diabetes mice)