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In the nervous system, the presence of GLP-1 receptors in the brainstem and their vagal connection suggests that the effects on taste may be secondary to central modulation rather than direct peripheral action (157, 170) but also, in vitro and clinical studies may suggest changes in perception of sweet, bitter and salt flavors as a reflection of GLP-1 on TBC (67, 178)

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Therefore, the model was parameterised by the apparent clearance (CL/ F ), volume of distribution ( V / F ) and the absorption rate constant ( k a )