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In many cases, a patient will experience recurrent or ongoing periods of chronic back pain that can prevent them from working or participating in an active, healthy lifestyle

Healthcare and medicine must evolve into a proactive public health system that is predictive, preventive, personalized, and participatory (P4 model) (263)

Achieving optimal long-term glycemic control as well as reducing the risk of cardiovascular (CV), neurodegenerative diseases, and mortality continues to be a challenge for a significant portion of patients with type 2 diabetes (T2DM) and type 1 diabetes (T1DM) worldwide [8,9,10,11,12,13,14]

Semaglutide, Tirzepatide, and Retatrutide all fall into this category, though each generation adds more receptor targets