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In summary, looking at the combined four studies here listed (Mann and Yates 1983

J Comput Chem 37:896912 Coulocheri SA, Pigis DG, Papavassiliou KA, Papavassiliou AG (2007) Hydrogen bonds in proteinDNA complexes: where geometry meets plasticity

The key consideration in designing such molecules is to avoid high thermodynamic costs and insurmountable kinetic barriers, ensuring easy obtainment of the desired structures

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