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One study explored mechanistic associations between GLP-1 functioning and mood disorders in humans: a post-mortem investigation showed that, compared with healthy controls, patients who had been diagnosed with mood disorders had lower expression of the gene encoding for GLP-1R in the dorso-lateral prefrontal cortex and the hippocampus, whereas this association was not observed in the brain tissue of people with schizophrenia 176

One trial found that exenatide had no overall benefit on alcohol consumption in individuals with AUD, except in participants with obesity [23]

Are GLP-1 drugs safe

Despite the possibility of adverse events, GLP-1 RAs continue to represent a crucial therapeutic modality for metabolic disturbances