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So when I prescribe 1000 mcg daily, I am giving a large dose knowing that the absorption fraction is small

Tanaka K, Sasayama T, Nagashima H, Irino Y, Takahashi M, Izumi Y, et al

In terms of outcomes, studies show that semaglutide users typically lose between 6 to 10 kilograms, while tirzepatide users may lose between 7 to 13 kilograms