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Looking at how these situations compare provides helpful perspective

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Mice fed with HFD and HepG2 cells treated by palmitic acid (PA) oleic acid (OA) exhibited significant reduction in Fe 2+ concentrations and obvious increase in Fe 3+ concentrations, and both showed changes in combinations of biomarkers based on ferroptosis, such as the upregulation of TFR1, and the inhibition of Nrf2 expression (71)