glp 1 comorbidities GLP-1 Agonists For Obesity In Non-Diabetic Patients: Game Changer Or Overhyped? A Critical Analysis GlobalRPH GLP-1 Impact: How GLP-1s Are

Insulin resistance is associated with increased serum concentration of IGF-binding protein-related protein 1 (IGFBP-rP1/MAC25)

10.1111/j.1749-6632.2009.04485.x 245

Many providers recommend a gradual taper or maintenance phase to support a smoother transition, but individual recommendations vary

In patients with DM2 the incretin response is diminished, but the insulinotropic effect of GLP-1 is conserved.28 Under normal conditions GLP-1 has a short half-life (approximately 2 min), as it is rapidly degraded by dipeptidylpeptidase 4, so GLP-1 analogues resistant to this enzyme have been developed for the treatment of DM2.29 arGLP-1: glucagon-like peptide 1 receptor agonist