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Introduction Pancreatic cancer (PC) is one of the most lethal malignant tumors with a poor prognosis and a high mortality rate ( The glutathione S-transferase (GST) family, the primary phase II metabolic enzymes involved in the detoxification of xenobiotic compounds and clearance of reactive oxygen species (ROS), includes eight distinct classes: mu, pi, sigma, alpha, omega, theta, kappa, and zeta ( Herein, we assessed the role of GSTM3 in PC and investigated its possible association with the prognosis of PDAC patients