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Semaglutide is a single-receptor GLP-1 agonist one of the most clinically studied weight-loss medications available, with an average 15% body weight reduction in trials

Managing First-Week Side Effects and When to Contact Your Provider Common first-week experiences include injection-site reactions (minor redness or tenderness), mild nausea, dry mouth, and subtle changes in food preferences

Adults require approximately 1.5 micrograms daily, but those at risk (vegans, older adults, or those with absorption problems) should take regular supplements or consume fortified foods to maintain optimal levels

Doctors often recommend that people continue some type of support after stopping semaglutide