The combination of lowering glutamate levels, while also providing adequate or increased micronutrient intake, may alter how the body handles the glutamate challenge, while simultaneously increasing antioxidant function, thereby ameliorating the downstream effects on oxidative stress (100, 101)
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MTX-induced apoptosis was significantly attenuated with all treatments except for NTZ-100, where, as depicted in Figures 5AD, Bcl-2 level was augmented while Bax was reduced, and consequently, Bax/Bcl-2 ratio was also reduced as well as caspase-3 activity all when compared to MTX group
This is experimental territory, and treating it otherwise would be irresponsible