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More recent studies have suggested the number of children with ASD that may manifest disruption in central folate metabolism may not be limited to those who are low-functioning or who have neurological symptoms (Frye et al., 1B demonstrates the target of HDFA in the context of CFD

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these effects are reviewed in (Patel and Kashfi, 2022)

Smolders LA, Meij BP, Onis D, Riemers FM, Bergknut N, Wubbolts R, Grinwis GC, Houweling M, Groot Koerkamp MJ, van Leenen D, Holstege FC, Hazewinkel HA, Creemers LB, Penning LC, Tryfonidou MA: Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies