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An in vitro study on bone marrow J774A.1 macrophages indicated that linezolid-induced inflammasome activation and IL-1 secretion, a property relatively unique to linezolid among other similarly acting antibiotics ( In vivo studies in different acute liver failure (ALF) animal models have shown the existence of cell death by necrosis resulted in rapid IL-1 precursor release and upregulation of IL-1 and IL-18, leading to tissue injury ( TNF- is a key cytokine in liver inflammation and disease

Lactate (metabolite of aggravate aerobic glycolysis) accumulation is the major reason of acidic pH in TME which is popularly termed as Warburgs effect [33, 34]

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