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That came out of animal model studies, where they gave large amounts of these drugs, and the animal model would get what's called C cell hyperplasia

Aardvark Therapeutics Sector: Oral gut-restricted bitter taste receptor agonists for hunger suppression HQ: San Diego, CA Year Founded: 2017 Origin Story: Aardvark Therapeutics was founded around a mechanistically distinct hypothesis: rather than suppressing appetite like GLP-1 drugs, the companys lead compound activates bitter taste receptors (TAS2Rs) confined to the gastrointestinal tract to trigger local release of satiety hormones, targeting hunger itself without systemic drug exposure

None of the analyses demonstrated an increased risk of PDAC associated with GLP-1RA 35,36,37 (Table 1)

Medication dosage should never be adjusted without consulting the prescribing provider. Resources We Trust Cleveland Clinic: Ozempic for Weight Loss: Who Should Try It and Will It Work