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targeted the IP3 receptor (IP3R) channels and induced the downstream pro-apoptotic Ca 2+ -signaling pathway via synthesizing a peptide named Bcl-2 IP3 receptor disrupter-2 (BIRD-2) mimicking the structure of the BH4 domain of Bcl-2

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The American Diabetes Association (ADA) Standards of Care emphasize individualized therapy selection, with GLP-1 receptor agonists considered preferred agents for many patients with type 2 diabetes who require additional glucose-lowering therapy beyond metformin, particularly those with established cardiovascular disease or chronic kidney disease

Both anti-diabetic treatments function by playing key modulatory roles in the incretin system