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Nocturnal enuresis (a pediatric indication - attributed to its antimuscarinic side effects) Contraindications: Drugs that inhibit monoamine oxidase (MAOI's) taken w/in 14 days, acute recovery period after a myocardial infarction, or history of drug hypersensitivity Side Effects: drowsiness dry mouth & eyes constipation orthotstatic hypotension mild tremor sweating agitation nausea tinnitus Overdose & Treatment: See Amitriptyline

A clinical map for separating biology from hype, and for understanding what the FDA policy shift changes

References 1 AbellaJ

Xia M-L, Xie X-H, Ding J-H, Du R-H, Hu G (2020) Astragaloside IV inhibits astrocyte senescence: implication in parkinsons disease