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Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons

Researchers are now studying whether therapies can produce: Greater fat loss Better preservation of skeletal muscle Improved muscle quality Stable or improved strength Better physical function Reduced visceral and ectopic fat Improved cardiometabolic health A 2026 phase 2 trial, for example, tested the investigational myostatin-pathway drug apitegromab alongside tirzepatide and found greater short-term lean-mass preservation than tirzepatide alone