It also reveals that bvPLA2 can enhance brain glucose metabolism and lower the hippocampuss neuroinflammatory reactions, potentially inhibiting AD progression (Ye et al., 2016b)
Some DNA methylation in the promoter regions of specific genes related to lipid metabolism (PPARG, PPARA), 212 low-density lipoprotein receptor-related protein 1 (LRP1), 213 lipoprotein lipase (LPL), 214 SREBF1/2, 215 and inflammation (stearoyl-CoA desaturase 1 (SCD1), chemokine C-C motif chemokine ligand 2 (CCL2), TNF-, and TGF-1) 216,217 are associated with adipose tissue dysfunction and could lead to metabolic disorders
& Aikawa, M
Interestingly, recent evidences indicate that GLP1R agonists can significantly reduce adverse cardiovascular events, renal dysfunction, and the incidence of stroke in the patients with diabetes 9,10,11,12