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Belching and flatulence are recognised gastrointestinal side effects of this medication, occurring as part of its broader tolerability profile

53 In mice, exenatide promoted polarization toward the anti-inflammatory M2 phenotype, associated with tissue repair, via cyclic adenosine monophosphate (cAMP) induction, which activates protein kinase A (PKA), leading to inhibition of c-Jun N-terminal kinase (JNK) phosphorylation and enhanced activation of signal transducer and activator of transcription 3 (STAT3) (Figure 2B)

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By reducing inflammation, semaglutide may indirectly help alleviate some types of pain, including pain caused by inflamed joints or tissues