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The esophageal, gastric, colorectal, and pancreatic cancers, in addition to HCC, are reviewed, and the role of melatonin in the regulation of specific pathways in each of the mentioned cancers, including Wnt/-catenin, PI3K/Akt/mTOR, MAPK/ERK, Hippo/YAP, NF- , IL-6 signaling, oxidative stress, apoptosis, and autophagy are discussed

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