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Even a minimal population of cells that survive these interventions may later acquire malignant potential, leading to disease relapse and a worsened prognosis for patients
It is reported that in ATC, lactate accumulation promotes globally protein lactylation, especially the histone lysine lactylation, activating the expression of multiple essential genes involved in ATC including CTGF, CCNE1, CDK1, KLF2, IL1B, and AURKB [85]
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One day after seeding, the cells were treated with either 50 nM MitoQ, 100 nM MitoQ, 10 M retinoic acid or vehicle, and incubated 37C for 7 days
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