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Clinical trials have shown that sitagliptin reduces hemoglobin A1c (a measure of average blood sugar over three months) by approximately 0.5 to 1.5 percentage points when used alone or in combination with other diabetes medications

This increased gut permeability can allow for high histamine foods to enter the bloodstream which otherwise would stay in the gut potentially leading to histamine intolerance

You can get recommended amounts of vitamin B12 by eating a variety of foods including the following: Beef liver and clams, which are the best sources of vitamin B12

N Engl J Med 2021;385:503-15.ArticlePubMed 28