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Relative to placebo, semaglutide not only reduced heavy drinking days, but led to reductions in multiple secondary outcomes, including alcohol craving, drinks per drinking day, total alcohol consumption, and alcohol exposure biomarkers

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In summary, pharmacological strategies centered on iron homeostasis are evolving from single-agent chelators to multi-target approaches involving small molecules, natural product extracts, and RNA technologies

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As mentioned in Chapter I, benzodiazepines cause profound perturbations throughout the brain, and abrupt withdrawal may be accompanied by uncontrolled release of dopamine, serotonin and other neurotransmitters which cause hallucinations in psychotic disorders as well as in alcohol withdrawal and cocaine, amphetamine and LSD abuse

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