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Estrogen also plays a role in appetite, interacting with two hunger-modulating hormones

Proc Natl Acad Sci USA 98 : 1159811603 Olchovsky D, Song J, Gelato MC, Sherwood J, Spatola E, Bruno JF, Berelowitz M (1993) Pituitary and hypothalamic insulin-like growth factor-I (IGF-I) and IGF-I receptor expression in food-deprived rats

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Simultaneously, Semax modulates dopamine D1 and D2 receptor density in the striatum, enhancing motivation and working memory without the tolerance development seen with direct dopamine agonists