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It is not, however, a human long-term safety clearance

The primary source of circulating GH is the somatotrophs of the anterior pituitary gland, however, it is also synthesised in other tissues including reproductive tissues, lymphoid tissues and the gastrointestinal tract (Harvey et al., 2000)

Mistake 1: Too short a break

Their advantage lies in the ability to sensitively capture the early cascade of events, ranging from impaired mitochondrial fatty acid oxidation to transport defects and tubular metabolic imbalance, thereby complementing the molecular trajectory of DKD that is not adequately reflected by conventional UACR measurements (Table 1)