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However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)
doi: 10.3389/fimmu.2023.1147724 147 TrindadeBCChenGY
Real-world data from clinics offering this combination protocol suggests enhanced fat loss compared to tirzepatide alone, but these observations come from uncontrolled clinical settings and cannot substitute for randomized controlled trials
Alternatively to MPT in the control of OMM permeabilization, Bcl-2 family members are also known to play a major function
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