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Journal of Pain Research, 12 , 31473159

Using glutathione or other depigmenting agents without clear medical indication and dermatologic supervision may inadvertently increase vulnerability to sun damage, especially in darker skin tones where pigmentation provides essential photoprotection

Patients with prior GLP-1 intolerance, significant psychiatric comorbidity, or substantial renal/hepatic impairment benefit from individualized evaluation rather than high-volume screening

112 In addition, selenium is capable of preventing the binding of nuclear factor kappa B to its nuclear response elements in DNA