doi:10.1093/jhered/esp055
Higher NAD+ means more fuel for mitochondrial function, better fat oxidation, and improved metabolic rate without the delivery limitations of oral NAD+ supplementation
Still, they are also a result of mitochondrial dysfunction, which occurs when mitochondria lose the protection of GSH, free radicals attack the mitochondria, and cellular energy decreases.8 Autoimmune conditions like multiple sclerosis, Crohns disease, rheumatoid arthritis, diabetes, Lyme disease, heavy metal load, organotoxins, and more all have mitochondrial dysfunction, low levels of GSH, and profound fatigue
Control of Redox State and Redox Signaling by Neural Antioxidant Systems