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Description

The medication is absorbed effectively from the abdomen, thigh, and upper arm

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting ALAS1-dependent heme synthesis

Dose ceiling: The MHRA has now approved a 7.2mg dose in the UK (January 2026), which produces an average weight loss of 20.7%

The number of participants using sodium-glucose cotransporter-2 (SGLT2) inhibitors was low at baseline (15%), but that number increased during the trial