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What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions

Taylor and Francis, Washington, DC, p 176 Ito E, Takai A, Kondo F, Masui H, Imanishi S, Harada K (2002) Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds