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The results of the 12-month phase 2b randomized controlled study (230) showed that oral spermidine supplementation did not significantly improve mnemonic discrimination or regulate AD biomarkers in older persons with subjective cognitive decline (SCD), despite strong preclinical performance

Additionally, behavioral changes in the 6-OHDA mouse model were reversed by the PI3K/Akt signaling pathway (Zhang et al., 2017a), and the reduced number of dopaminergic cells and the levels of dopamine and its metabolites DOPAC and HVA were restored ( Vitamins Vitamins in the body have always been regarded as one of the most bioavailable nutrients