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Hyaluronic acid is an FDA approved treatment option for knee osteoarthritis and is a recommended treatment for knee pain due to OA by numerous highly regarded national and international medical associations What To Stay Aware Before Booking A Pain Treatment In some cases pain relief onset may take longer than other treatments listed, or may require 2-3 treatments before beginning to experience pain relief Some hyaluronic acid treatments are contraindicated for patients with severe bird (avian) allergies, including patients with allergies to avian proteins, feathers, or egg products