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A study has found that NRF2 is responsible for maintaining the self-renewal function of glioma stem cells (GSCs), supported by the evidence that NRF2 deficiency attenuated the tumorigenicity of GSCs in the xenograft model [129]

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Immunotherapy used in cancer, like immune checkpoint inhibitors, also are associated with SCAR-like reactions, including SJS/TEN-like reactions, that may be difficult to distinguish from true SJS/TEN and often show histopathology more consistent with bullous lichenoid drug eruption or bullous pemphigoid [9,10,11]

Reconstituted solutions should not be frozen