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also showed significant increases in serum concentrations of asymmetric dimethylarginine (ADMA), enhanced inhibition of NOS, enhanced catabolism of Arg, increased levels of ornithine (Orn) and proline (Pro), and decreased Arg/Orn ratio in patients with asthma and obstructive sleep apnea (OSA)
Front Chem 11:1279384 Eckstein A, Philipp S, Goertz G, Banga J, Berchner-Pfannschmidt U (2020) Lessons from mouse models of Graves disease
This results in perturbations in biochemical activities of enzymes, transport proteins, structural proteins, receptors and other proteins such as enzymes that control iron and calcium homeostasis