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Description

Participants saw rapid initial loss through weeks 4 to 12, peak velocity between weeks 12 and 24 (roughly 1.8 pounds per week), gradual slowing between weeks 24 and 36, and a plateau or near-plateau by weeks 44 to 48

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In receptor-deficient systems, the peptide does not produce measurable changes in lipolytic signaling, supporting the conclusion that its effects are mediated through adrenergic pathway engagement rather than direct hormone receptor activation

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