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The unbound B12 then combines with another protein (called intrinsic factor, which is secreted by cells in the stomach) before it is absorbed by the body in the small intestine and put to work

NHS and BNF recommendations typically include: Oral cyanocobalamin 50150 micrograms daily for dietary deficiency Intramuscular hydroxocobalamin for malabsorption or neurological involvement (initially 1 mg every other day for 1-2 weeks for neurological symptoms, or 1 mg 3 times weekly for 2 weeks without neurological symptoms

GLP-1RA = GLP-1 receptor agonist

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