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Results Although overall TMAO production did not change between the dietary fiber and placebo group ( p -value = 0.26, 95% CI), subgroup analysis revealed that fiber supplementation attenuated TMAO formation following beef intake in participants with lower habitual meat consumption ( 40 years, smoking, diseases affecting nutrient absorption, digestive, metabolic, or excretory function, chronic diseases from the medical history (e.g

1 Introduction Gastrointestinal diseases are highly prevalent worldwide and account for a significant portion of global disease burden (1) and healthcare costs (2)