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Methods 9 , 853854 (2012)

Before the big trial, Athira ran a smaller Phase 2 proof-of-concept study called ACT-AD, in 77 patients

Inactivating mutations in the EPHX2 gene that encodes sEH, as well as pharmacologic inhibition of sEH, leads to the stabilization of cellular levels of EETs, as well as other epoxy fatty acids, resulting in beneficial outcomes in several conditions

Circulation 124 , 19962019 (2011)