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5.5 Conclusion and future direction Recognizing the limitations of conventional delivery routes in targeting the CNS, IN administration provides a non-invasive alternative that not only bypasses the BBB but also avoids hepatic first-pass metabolism

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The Science Behind Melanotan II, 10mg Product Name: Melanotan II Strength: 10mg Chemical Name: Synthetic Cyclic Heptapeptide (Melanocortin Receptor Agonist) CAS Number: 121062-08-6 Molecular Formula: CHNO Molecular Weight: 1024.2 g/mol Amino Acid Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH (cyclic) Appearance: White to Off-White Lyophilized Powder Classification: Neuropeptide Signaling Research Compound Purity: Verified by analytical testing prior to release Analytical Methods: HPLC, Mass Spectrometry (MS)

Therefore, synthetic GLP-1 analogs with resistance to degradation by DPP-4 were developed