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The principal function attributed to ICP34.5 involves enhancing viral propagation across peripheral tissues alongside central nervous systems, contributing significantly toward HSV, and inducing neurovirulence via various mechanisms including protein phosphatase I (PPI) dephosphorylating eIF2, thus preventing shutoff from host protein synthesis while enabling continuous production (11, 30, 31)
Li, W.-X., Dai, S.-X., Zheng, J.-J., Liu, J.-Q., & Huang, J.-F