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Plant sterol esters from -linolenic acid activate SIRT1, downregulating NLRP3 and ASC expression, reducing colocalization with cleaved caspase-1, and lowering GSDMD cleavage, thereby inhibiting hepatocyte pyroptosis and slowing MASH progression in mice

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A gradual taper prevents these rebound effects and allows your metabolism to recalibrate more smoothly

Interestingly, the next generations of mice had more profound defects (85, 169)