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This regulation is absent in c-Met-deficient primary mouse hepatocytes, leading to the overproduction of ROS, increased oxidative stress, and heightened sensitivity to apoptosis-promoting agents

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Comprising 12 transmembrane domains and 555 amino acid residues, URAT1 is encoded by the SLC22A12 gene, sharing a noteworthy 30% homology with the rat organic cation transporter 1 [55]