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Options include stepping back to a previous tolerated dose for an additional 4 weeks, reducing the current dose by half and escalating more slowly, or adding prescription anti-nausea medication (ondansetron is commonly used)
Model curation provides researchers with the ability to obtain, adapt and implement such mathematical models, as outlined in this study, and is therefore a powerful tool in the arsenal of any systems biologist, pharmacologist or toxicologist
One protein accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities
Heres comprehensive guidance on minimizing risks and ensuring appropriate use
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