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Thus, we isolated epithelial cells from the bladders of mice with different disease histories, established primary USC lines, propagated them in cell culture, and formed polarized and fully differentiated urothelium in vitro, which displayed morphological phenotypes that resembled the urothelial remodelling phenotypes observed in vivo 6

Users who run continuous high-dose protocols often report diminishing returns, while those who cycle seem to maintain consistent responses over months and years of use

doi: 10.1172/JCI157515