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Debido a sus propiedades como antioxidante, y a su alta concentracin intracelular y su amplia distribucin, est bien establecida su funcin como un potente mecanismo de defensa contra el estrs oxidativo y electroflico

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284 Emerging epigenetic data suggest that GLP-1 RAs may decelerate biological aging via DNA methylation modifications at loci associated with inflammatory and metabolic regulation, consistent with observed reductions in biological age

Given the dual role of butyrate in regulating ferroptosis, future research should first clarify the specific molecular mechanisms by which butyrate inhibits ferroptosis in OA chondrocytessuch as through the AMPK/NRF2 pathway or downregulation of factors like LCN2and its interactions with pathological microenvironments including inflammation and ECM degradation