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WD-reduced hippocampal neurogenesis was normalized by GE2 treatment consistent with effects mediated by GLP-1 receptor agonist treatment in young adult male rodents (9498) and adult and aged female mice (90)
In fact, clinical trial data show GLP-1-treated groups had slightly lower rates of depressive symptoms compared to controls in landmark trials like the STEP studies
It also appears to improve blood flow and oxygen delivery to muscles
This study is a global, randomized, double-blind, placebo-controlled clinical trial (n=11000) aimed at evaluating the effectiveness and safety of Zilebesiran (300mg, subcutaneous injection, once every 6 months) combined with standard treatment (OC) compared to placebo combined with SOC in reducing the incidence of major cardiovascular adverse events (MACE) in hypertensive adult patients with diagnosed cardiovascular disease or poor blood pressure control at high risk of cardiovascular disease
